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Ethical Clearance: Yenepoya ethics committee-1 approved our study protocol number 2018/061 titled 1 arteria zygomaticoorbitalis buy generic cardura 2 mg line. Guidelines for prevention of catheter associated urinary tract infection blood pressure kit purchase cardura 4 mg free shipping, available from blood pressure after eating cheap cardura 4 mg with mastercard. Introduction Corresponding Author: Ola Omar Abou Zeid Dermatology arteria inflamada del corazon buy 4mg cardura visa, Venereology and Andrology Department, National Research Centre, Cairo, Egypt Address: 33 El Buhouth StAd Doqi, DokkiCairo Governorate 12622 Mobile No. Recent epidemiological studies reported that the prevalence of vitiligo ranged from 0. However, recent reports demonstrated that autoimmunity 146Indian Journal of Public Health Research & Development, March 2020, Vol. Such triggers can induce oxidative stress in melanocytes with subsequent cellular disruptions and upregulation of a number of cytokines and chemokines5,6. Consequently, this upregulation attracts inflammatory cells infiltration into the epidermal and follicular tissues which lead to the development of histopathological pattern of vitiligo7. Effective treatment is critical in order to optimize the physical and psychological outcomes of vitiligo patients. Materials and Method Study Design and Sampling: the present study was a non-randomized, comparative, study that was conducted at dermatology outpatient clinic of National Research Centre and National Institute of Laser Enhanced Science of Cairo University from August 2017 till March 2019. All patients should have stable refractory lesions with no improvement to conventional treatments. We excluded pregnant or breastfeeding women, active infection, or other autoimmune diseases. In addition,age and gender-matched healthy volunteers were included as a control group. A non-probability, consecutive, sampling technique was utilized to recruit eligible patients. The sample size calculation was done using Stats Direct statistical software version 2. The study included 45 subjects who were divided into two groups: Laser group which included 30 patients with stable non segmental vitiligo and control group which included 15 healthy volunteers. Interventions: Alleligible participants were exposed to sunlight daily for three months. The sun exposure was applied to the affected area at the 5th day after each session and the non-affected area was protected by sunscreen. The supernatant serum was separated in ependorph tubes and stored at -80°c till the tie of analysis. This step was done in the Medical Biochemistry Indian Journal of Public Health Research & Development, March 2020, Vol. Correlation between various variables was done using Spearman rank correlation equation. In contrary, there was statistically significant difference between patients group and control group in terms of family history (p <0. Results In the present study, 30 patients with vitiligo and 15 age and sex-matched controls were included. Though the exact pathogenesis of vitiligo is still unclear, the oxidative stressand the infiltration of inflammatory mediators have been well-established as major contributors for the progressive, autoimmunemediated, destruction of melanocytes seen in vitiligo18. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. The role of cytokines and chemokines in the T-cell-mediated autoimmune process in alopecia areata. Fractional Carbon Dioxide Laser as an &quot;Add-on&quot; Treatment for Vitiligo: A Meta-analysis with Systematic Review. Combination treatment by 10 600 nm ablative fractional carbon dioxide laser and narrowband ultraviolet B in refractory nonsegmental vitiligo: A prospective, Indian Journal of Public Health Research & Development, March 2020, Vol. Efficacy of Fractional Carbon Dioxide Laser in the Treatment of Mature Burn Scars.

The calculated triple-numbers are applied to a sphere-shaped triangle (asomatograph) on the eachside of peak are like marginal types;in the centre arteria y vena femoral cardura 2mg free shipping, balanced types; and inside medium types(Carter hypertension guidelines order 4 mg cardura free shipping, 1996)2 arteria hipogastrica cardura 4mg on line. The estimations of each segment and their common proportion express the particular individual variations in the shape and composition of a human body and its parts hypertension in 9th month of pregnancy buy cheap cardura 4 mg online. As the case with every regular human needs, the expert guidelines for systemic physical activity for the PwDs is very scarce. From the last thirty years, we have been seeing the importance of regular physical activity in the open sunlight as it was also highlighted by (Rimmer, Braddock, and Pitetti, 1996)4. But despite all this publicity, the message seems to be reaching only a small percentage of Americans. Much of the rest of the country remains sedentary, and despite knowing very little about the physical activity habits of persons with disabilities, it is generally accepted that they are at the forefront of this sedentary existence". Nevertheless presently any studies have been hardly conducted on mentally challenged children, especially in India. Study Population and Sampling: the targeted population included male adolescents with mental disabilities. A purposive sampling of adolescents was used to collect sample and retrieved information. Purposive sampling is suitable for the difficult-to-reach special target population stated by (Neuman, 2006)5. Equipment for Somatotype: Anthropometric equipment include a stadiometer and headboard, weighing scale, small sliding caliper, flexible steel tape measure, and a skin fold caliper. For accurate measuring of biepicondylar breadths the caliper branches must extend to 10 cm and the tips should be 1. Skinfold caliper should have upscale interjaw pressures of 10 gm/mm2 over the full range of openings. Measurement Techniques: the following procedure was adopted from (Carter and Heath, 1990)7 for analyzing anthropometric somatotype for that we are needed to calculate ten (10) anthropometric bodily measurements i. The following table presents descriptive statistics of 10 anthropometric variables, which were also Material and Method Participants of the Study:25 (male) participants, age ranging in between 14 - 18 years, trainable and educable mentally challenged without any multiple disabilities were selected from Special School for Mentally Challenged People under Department of Teacher Training & Non-formal Education, Jamia Millia Islamia, New Delhi. Table 1: Descriptive Statistics of Anthropometric Measurements of Mentally Challenged Participants. Figure 1: the Mean Somatotype for All the Profiles 416Indian Journal of Public Health Research & Development, March 2020, Vol. Table 3: Percentage of profiles which fall under each of the significant somatotype categories. And from Table 3, graphical representations of all the major somatotype categories as per the somatotype category chart are presented and given below in the Figure 2, 3, & 4. The Figure 2,showsthe total number of people and total number in percentage which fall under the category of Balanced Mesomorph (4%), Balanced Ectomorph (8%) from overall Somatotype profiles data. The Figure 3,shows the total number of people and total number in percentage which fall under the category of Mesomorph-Endomorph (8%), Mesomorph-Ectomorph (12%) from overall Somatotype profiles data. The Figure 4,shows the total number of people and total number in percentage which fall under the category of Ectomorphic Mesomorph (28%), Mesomorphic-Ectomorph & Endomorphic Mesomorph are (12%), Mesomorphic endomorph (16%) from overall Somatotype profiles data. This shows that participants found greater in number in mesomorphic and ectomorphic in comparison to endomorphic characteristics. In balanced category of Mesomorph, mentally challenged participants are found lowered in comparison to Ectomorph from overall Somatotype profiles data. Result clearly indicates that mentally challenged participants have low level of body fat and observed more percentage in mesomorphic and ectomorphic category. It is very important for mentally challenged participants to get involved in physical activity because they have improper skeleto-muscular development system and having unbalanced lifestyle. It is necessary for mentally challenged participants to involve in special physical education program to develop their fitness level. Acknowledgement: the authors want to thank all the children and their parents that participated in the study for their understanding and dedication to the project. Principal, teachers of the Department of Teacher Training & Non-formal Education, Jamia Millia Islamia, New Delhi and at last the Ministry of Social Justice & Empowerment, New Delhi.

Table 3: Exhibiting mean arteriographic embolization purchase cardura 2mg online, standard deviation and t-test value of obtained scores of mental health factor adjustment of juvenile delinquents in reference to Patanjali yoga practice Control Group (N=35) Group Test Pre Test Post Test Mean 23 hypertension kidney pain purchase cardura 2 mg overnight delivery. Table 4: Exhibiting mean blood pressure apple watch cardura 4 mg without prescription, standard deviation and t-test value of obtained scores of mental health factor autonomy of juvenile delinquents in reference to Patanjali yoga practice Control Group (N=35) Group Test Pre Test Post Test Mean 9 prehypertension definition quality 4mg cardura. Table 5: Exhibiting mean, standard deviation and t-test value of obtained scores of mental health factor Intelligence of juvenile delinquents in reference to Patanjali yoga practice Control Group (N=35) Group Test Pre Test Post Test Mean 11. There is significant effect of Patanjali Yoga practice on mental health factors which are emotional stability, adjustment and self concept. It is also revealed that there is insignificant effect of Patanjali Yoga practice on mental health factors which are autonomy, security-insecurity and intelligence. It was also found that Patanjali yoga practice do not effect moral judgment of juvenile delinquents. Hence, after having conversation with authority it was clear that there was a positive change seen amongst juvenile delinquents due to Patanjali Yoga practice and they want these yoga practices to be contionusly scheduled from time to time. Ethical Clearance: Not required as per study Source of Funding: Not Applicable Conflict of Interest: Nil 1. Psychological factors at work and musculoskeletal disease: a review of the literature. Harried lawyers still their minds with yoga and meditation, American Bar Association. Dworkis S, Recovery Yoga: A Practical Guide for Chronically Ill, Injured, and Post-Operative People, New York: Three Rivers Press, 1997. It leads significant harm to the physical, psychological and social health of individuals, families and communities as a whole. Wives of the alcoholics are the persons who suffer the consequences of alcoholism and its effects the most. Materials and Method: Quantitative approach with descriptive survey research design was adopted in the study. Results: Shows that mean quality of life score of wives of alcoholics in physical domain (11. Conclusion: the study findings revealed that wives of alcoholics are having poor quality of life. Hence need to adopt effective interventions to promote the wellbeing of the wives of alcoholics and to improve their quality of life. Introduction Alcoholism is a serious global health concern which affects not only the individual but also his family and Corresponding Author: Dr. It creates major problem to the family members especially the wife and they face untold misery. Wives of alcoholics first they try to adjust with the problems but finally they begin to feel depressed, confused, and even guilty1. The wife of an alcoholic, who enters into marital life with a heart full of expectations, becomes exhausted, when she faces tough life situations from alcoholic husband. Social influence process plays an important Indian Journal of Public Health Research & Development, March 2020, Vol. In Indian society, alcoholism is one of the major social problems which have negative effects on the spouse of an alcoholic4. This problem directly affects the health of family structure, feeling of hatred, self pity, avoidance of social contacts, divorce, irresponsibility of husbands, suicide, homicide, broken home, poor academic performance of children, poverty are all the outcome of this evil. The community support system, including the mental health services can be a good resource for them to bring them out of this contagious problem. From all the above statistics it is evident that there is an increased with multi factorial problems among the wives of alcoholics, which decreases the quality of life. Hence the present study was undertaken to assess the quality of life of wives of alcoholics. The need and purpose of the study was explained to the participants in their local language and confidentiality was assured. Results Section 1: Description of Sample characteristics: this section deals with the description of the baseline characteristics of 132 subjects presented in frequency and percentage. Materials and Method A quantitative approach with descriptive survey research design was adapted in this study to meet the objectives.

Sampling of Cell-Based Immunotherapy Companies with Critical Milestones in the Past 12 Months AdaptImmune Argos Therapeutics Cell Medica Coronado Biosciences Dendreon Immunocellular Therapeutics Immunovative Therapies Kiadis Pharma Newlink Genetics Northwest Biotherapeutics NovaRx Opexa Therapeutics Prima BioMed Industry-Sponsored Cell-Based Immunotherapy Trials 13 Late-Stage 52 Mid-Stage 10 Early-Stage Ongoing Industry-Sponsored Cell Therapy Trials by Phase 54 Late-Stage 43 companies 209 Mid-Stage 114 companies 63 Early-Stage 49 companies Industry-Sponsored Cell Therapy Trials by Location U blood pressure dehydration order 2 mg cardura overnight delivery. The clinical trials database hosted by the Journal of Gene Medicine currently reports over 1 blood pressure chart dr oz cardura 4mg low cost,240 open gene therapy clinical trials in 31 countries arrhythmia list buy generic cardura 2 mg on line. While the largest segment of gene therapies in development target cancer (nearly 65 percent) blood pressure chart gender generic 2mg cardura overnight delivery, the Journal of Gene Therapy clinical trial database reports the next largest category of gene therapy trials (8. A significant amount of gene therapy research and clinical development is also targeting cardiovascular disease, neurological disease, and ocular disease, many of which are classified as regenerative gene therapies. For cardiovascular disease in particular, the expectation is that gene therapy will provide a new avenue for therapeutic angiogenesis, myocardial protection, and regeneration and repair of damaged or diseased heart tissue. Notable Gene Therapy Commercial Milestones 2013: bluebird bio signs a global strategic collaboration with Celgene Corporation to discover, develop and commercialize novel disease-altering gene therapies in oncology. Number of Gene Therapy Clinical Trials1 Phase 1: 1098 Phase 1/2: 350 Phase 2: 307 Phase 2/3: 16 Phase 3: 67 Phase 4: 2 Single Subject: 3 Indications Addressed by Gene Therapy Clinical Trials1 Diseases: Cancer: 1186 Monogenic: 161 Cardiovascular: 155 Infectious: 147 Neurological: 36 Ocular: 28 Inflammatory: 13 Other: 25 16 For Cardiovascular disease in particular, the expectation is that gene therapy will provide a new avenue for therapeutic angiogenesis, myocardial protection, and regeneration and repair of damaged or diseased heart tissue. These advanced therapies will revolutionize the way we improve the health and quality of life for millions of people worldwide. These complex products are being designed and developed for a wide variety of disorders and across numerous tissue types-bone, cartilage, skeletal muscle, skin, blood vessels, nerve tissues, ocular tissues, and whole organs. In addition to having critical therapeutic utility, these technologies, through use of engineered 3D tissue models and micro-organs, have innovative diagnostic and research applications for the testing of drug absorption and metabolism, toxicity, and pathogenicity. In researching these companies, we identified 120 products that vary in development from preclinical through marketed. These multifaceted products will be comprised of multiple components, in specific configurations, with unique manufacturing schemes and will be regulated as biologics or combination products requiring pre-market review, extensive safety testing and lengthy trials. From our research, the sector has a strong and growing pipeline of tissue-engineered and biomaterial-based combination products across a wide variety of tissue types and clinical applications. By definition, these composite tissue-engineered products are comprised of multiple components (cells, scaffolds, growth factors, etc. In general, they are built from components in the following three areas: n Biomaterials and Scaffolds: these are biologic, synthetic or semi-synthetic or hybrid matrices specifically designed to direct the organization, growth, and differentiation of cells to form functional tissue by providing physical, structural, and chemical cues. Additional opportunities exist in the development of enabling methodologies for the proliferation and differentiation of these cells. Biomolecules: these include angiogenic factors, growth factors, and differentiation factors like bone morphogenic proteins currently used in various bone-promoting products. Many of these products are comparatively simple -they are comprised of minimally manipulated components. Moving to the next generation of tissue-engineered biomaterial- and scaffold-based technologies for the delivery of drugs, cells and eventually genes is far more complex with regard to design, development and ultimately commercialization. In addition to suppliers and product developers, technology and service providers that support next generation tissueengineered products are emerging. These include the companies focused on developing technologies that support that unique assembly, manufacture, and delivery of the complex multicomponent tissue-engineered products. In addition, and specific to engineered products, is the focus on the biomechanical aspects of design including properties of native tissues, identification of minimum properties required of engineered tissues, mechanical signals regulating engineered tissues, and efficacy and safety of engineered tissues. Finally, informatics are required to support tissue-engineered products including gene and protein sequencing, gene expression analysis, protein expression and interaction analysis, quantitative cellular image analysis, quantitative tissue analysis, in silico tissue and cell modeling, digital tissue manufacturing, automated quality assurance systems, data mining tools, and clinical informatics interfaces. A number of compounds and factors have been identified that exhibit a powerful influence on stem cell behavior. These not only have the potential to help enable the development of viable cell therapies but may also be constituted as oral drugs given to patients to support endogenous cellular regeneration. As adjuncts to cell therapies or tissueengineered products to enhance their intended therapeutic effects n Small molecules and biologics play a pivotal role in regenerative medicine through a number of means including: the ex vivo expansion and maintenance of cell lines used in the production of cell-based therapies n An example of a company pursuing the development of a small molecule-based adjunct for cell therapy is ate Therapeutics is pursuing the development of a small molecule-based adjunct for cell therapy. Companies developing and distributing small molecules and biological reagents for use in ex vivo stem cell manipulation and expansion include Akron Biotechnologies, BioLife Solutions and CellGenix, among others. As regenerative medicines which induce resident cells/tissues, through molecular signaling pathways, to be replaced, repaired or regenerated n n In this instance, small molecules and biologics are serving as epigenetic factors that control genetic pathways toward regeneration. As research continues to expand our understanding of molecular targets and pathways that control stem cell self-renewal, expansion and differentiation, we will also uncover new strategies that target the delivery of drugs to safely regenerate tissue function and avoid undesired effects such as hyperplasia, fibrosis and cancer. By way of example, Fate Therapeutics is leveraging its understanding of adult stem cell biology to advance its Wnt-based protein regenerative platform for muscular dystrophy and muscle degenerative disorders. The disease models, which combine human cortical neurons, motor neurons, microglia and astrocytes in a dish, are used by iPierian to discover and validate novel biologic and small molecule drug candidates. There is a pressing need to develop more accurate tools for predicting toxicity in drug candidates earlier in the drug development pipeline, producing safer medicines.