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Timothy A. Sanborn, MD

  • Head, Division of Cardiology
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  • Professor of Medicine, Northwestern
  • Feinberg School of Medicine
  • Evanston, Illinois

The dorsal cavity is subdivided into the cranial cavity (which contains the brain) and the vertebral cavity or canal (which incorporates the spinal cord) treatment for long term shingles pain purchase 500mg azulfidine with mastercard. The ventral body cavity is subdivided by the diaphragm right into a superior thoracic cavity and an inferior abdominopelvic cavity. The thoracic cavity is subdivided into three smaller cavities, the pericardial cavity, the mediastinum, and the pleural cavity. These methods embrace the integumentary, skeletal, muscular, nervous, endocrine, cardiovascular, lymphatic, digestive, respiratory, urinary, and reproductive techniques. The group ranges of the physique embody the atoms, molecules, macromolecules, organelles, three. Essentials for life embrace particular nutrients similar to meals, water, and oxygen in addition to strain and heat. The main physique cavities are the cranial cavity (housing the brain), thoracic cavity (inside the chest), and abdominopelvic cavity (inside the abdomen and pelvic areas). The systems of the body and their organs are as follows: Integumentary: pores and skin, hair, nails, sebaceous (oil) glands, sweat glands Skeletal: bones, ligaments, cartilages Muscular: muscular tissues, tendons Nervous: mind, spinal wire, nerves, sensory organs Endocrine: hypothalamus, pituitary, thyroid, parathyroid glands, pancreas, pineal gland, adrenal glands, thymus Cardiovascular: coronary heart, blood, arteries, veins, capillaries Lymphatic: lymphatic vessels, lymph nodes, thymus, spleen, lymph fluid Digestive: mouth, tooth, salivary glands, tongue, pharynx, esophagus, abdomen, liver, gallbladder, pancreas, small intestine, large intestine, rectum, anus Respiratory: nostril, nasal cavity, pharynx, larynx, trachea, bronchi, lungs Urinary: kidneys, ureters, urinary bladder, urethra, penis Reproductive: ovaries, uterine tubes, uterus, vagina, clitoris, and vulva in the female and scrotum, testes, epididymides, ductus deferentia, seminal vesicles, prostate gland, bulbourethral glands, penis, and urethra in the male A. Inferior, below another physique part; superior, above another physique part; anterior (ventral), eight. Body planes include coronal (frontal), dividing the body into anterior and posterior portions; sagittal, dividing the physique lengthwise into right and left parts; and transverse (horizontal), dividing the body into superior and inferior portions. The lungs are lined with a membrane referred to as the parietal pleura and covered by a membrane referred to as the visceral pleura. The parietal peritoneum lines its walls, and the visceral peritoneum covers every organ. The nine belly areas are the left hypochondriac, epigastric, right hypochondriac, left lumbar, umbilical, proper lumbar, left iliac (inguinal), hypogastric, and proper iliac (inguinal) regions. A positive suggestions mechanism is one that makes situations move away from the normal state, stimulating further modifications. A unfavorable suggestions mechanism is one that stops the correction of deviations from doing too much, which might probably harm the body. The upkeep of a relatively fixed internal surroundings in the human physique is termed as A. Support, safety of soppy tissue, mineral storage, and blood formation are features of which system Integumentary system the chemical or molecular stage of group begins with and forms Left and right hypochondriac areas Which of the next is an example of optimistic feedback Body temperature regulation A reduce passing by way of the midline of the body that divides it into equal left and proper halves is referred to as which of the following planes Compare the operation of positive and unfavorable suggestions mechanisms in sustaining homeostasis. Overview Chemistry is the science that offers with the structure of matter, and the study of the human physique begins with chemistry. It is essential for other sciences, together with physiology, pathology, pharmacology, and microbiology. Each cell of the body incorporates organelles made up of macromolecules, and the cells then compose tissues and organs. Atoms, Molecules, and Chemical Bonds Basic Chemistry Studying basic chemistry and its relation to anatomy and physiology is essential as the complete human body is made up of chemicals. Basic chemistry takes into account matter, the states of matter, and vitality in all its varied sorts. For example, due to differences in gravitational pull, your physique weighs barely more at extremely low sea levels and slightly much less at extremely excessive sea ranges. The human body contains examples of all the composition of matter and adjustments in its composition are the focuses of the study of chemistry. If you perceive chemistry, your understanding of anatomy and physiology improves. Chemicals of the body embody water, proteins, carbohydrates, lipids, nucleic acids, and salts as well as meals, drinks, and medications. Copper, iron, gold, silver, aluminum, carbon, hydrogen, and oxygen are all examples of elements. The periodic desk of elements is a tabular association of the chemical components, and organized on the premise of atomic numbers, electron configurations, and recurring chemical properties. Protons and neutrons are related in dimension and mass; however, protons bear a positive electrical cost, whereas neutrons are electrically impartial (uncharged). The mass of a bigger object, such because the human body, is the sum of the lots of all its atoms. Thus, hydrogen (H), the only atom, has one proton, giving it the atomic number 1, whereas magnesium, with 12 protons, has the atomic quantity 12. For example, oxygen has eight protons and eight neutrons, so its atomic weight is 16. Radioactivity is the emission of energetic particles known as radiation, which happens because of instability of the atomic nuclei. The nuclei of certain isotopes (radioisotopes) spontaneously emit subatomic particles or radiation in measurable quantities. Strong radioactive isotopes are harmful as a outcome of their emissions can destroy molecules, cells, and residing tissue. For diagnostic procedures, weak radioactive isotopes are used to diagnose structural and useful characteristics of internal organs. Radiation is principally recognized as one of three frequent varieties: alpha, beta, or gamma. For instance, two kinds of iodine, 125-iodine and 131-iodine, can substitute for 126-iodine in chemical reactions. Iodine may be utilized in diagnostic procedures involving the thyroid gland to detect thyroid most cancers. The traits of dwelling and nonliving objects outcome from the atoms they comprise and the way those atoms combine and interact. When two completely different kinds of atoms mix, they form molecules of a compound (see "Covalent Bonds" later in this chapter). Compounds are chemically Electron Molecules and Compounds the time period molecule is outlined as any chemical structure that consists of atoms held collectively by covalent bonds (involving the sharing of electrons between atoms). A molecule is the smallest particle of a compound that still has the specific characteristics of that compound. Examples of compounds include water (a compound of hydrogen and oxygen), dry ice (frozen carbon dioxide), table sugar, baking soda, alcohol (as utilized in beverages), pure gas, and most medicinal medication. A molecule of a compound has particular types and amounts of atoms (see "Hydrogen Bonds" later in this chapter). Mixtures Mixtures are substances containing two or extra parts which may be physically intermixed. An instance is the varied powders combined collectively in a capsule with an energetic drug. Colloids, solutions, and suspensions are every found in both residing and nonliving systems. Living material is essentially the most complex combination of all, containing colloids, solutions, and suspensions-all of which work together with one another. Light is scattered when proven by way of a colloid, meaning the trail of the sunshine beam is seen. An example of a nonliving colloid that undergoes a sol�gel transformation (when refrigerated) is a gelatin product corresponding to Jell-O. Also, the reverse process happens when these merchandise are heated, similar to by sunlight, with their state returning to a liquid. In residing cells, the semifluid material often identified as cytosol undergoes sol�gel transformations. Cytosol has many dispersed proteins, and these transformations are the basis for cell division, cell form changes, and other necessary actions. One pattern of any part of the mixture will reveal an similar composition to some other pattern of the mixture. Examples embrace ocean water (which is a combination of water and salts) and environmental air (which is a mixture of gases).

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It is mostly stored in the skeletal muscle and liver pain treatment ladder buy cheap azulfidine 500mg on-line, and is extremely branched (like starch) and made up of large molecules. When the blood sugar degree drops rapidly, the liver cells break down glycogen releasing its glucose models into the blood. Because of many Monosaccharides Simple sugars have 6 carbon atoms, 12 hydrogen atoms, and 6 oxygen atoms (C6H12O6). Ribose and deoxyribose differ from the others in that they every comprise five atoms of carbon. Monosaccharides are typically named primarily based on the number of carbon atoms they contain. Carbohydrates are primarily utilized by the physique for ever-ready, easy-to-use mobile fuel. Glucose is the first form of fuel used by most cells, which in general can only use a few forms of different easy sugars. Remember that glucose is damaged down and oxidized inside cells, during which era electrons are transferred. There are some sugars in human genes, whereas others are attached to exterior cell surfaces and used to guide interactions between cells. Lipids Lipids are insoluble in water, however could dissolve in different lipids, oils, ether, chloroform, or alcohol. Lipids include a selection of compounds such as triglycerides, phospholipids, and steroids with very important cell capabilities. Like carbohydrates, fats molecules additionally contain carbon, hydrogen, and oxygen however have far fewer oxygen atoms than do carbohydrates. These fat molecules are generally known as triglycerides, also called impartial fats, a subcategory of lipids that features fat (when solid) and oils (when liquid). These molecules are fashioned by the condensation of one molecule of glycerol, which is a three-carbon sugar alcohol (a modified easy sugar). Triglycerides contain different saturated and unsaturated fatty acid combinations. Those with the most saturated fatty acids are known as saturated fat and people with probably the most unsaturated fatty acids are called unsaturated fat. Via dehydration synthesis, fat synthesis involves the attachment of three fatty acid chains to only one glycerol molecule. The fatty acid chains vary, however the glycerol is all the time the identical in all triglycerides. Fatty acids are linear chains of carbon and hydrogen atoms generally known as hydrocarbon chains, with an natural acid group located at one finish. Fats and oils, after being consumed, should be damaged right down to their less complicated constructing blocks before they are often absorbed. Deeper body tissues are protected from heat loss and mechanical trauma by triglycerides, which are largely discovered beneath the skin. Women have a thicker subcutaneous fatty layer than males, which helps to insulate them from colder temperatures. Saturated fats is defined as containing carbon atoms which may be certain to as many hydrogen atoms as attainable turning into saturated with them. The diploma of saturation determines how stable the molecule is at varied temperatures. These straight fatty acid chains have saturated fat molecules packed carefully collectively at room temperature making them stable. Fatty acid molecules with many double-bonded carbon atoms are known as polyunsaturated. Many kinds of margarines and baked merchandise comprise trans fats, which are oils solidified by including hydrogen atoms at the websites of carbon double bonds. Trans fat are actually recognized to increase risks for coronary heart disease much more considerably than solid animal fat. Oppositely, the omega-3 fatty acids from coldwater fish are recognized to decrease the risk of coronary heart illness and certain inflammatory diseases. Fatty acid molecules with one double bond between carbon atoms are referred to as unsaturated. Therefore, triglycerides with either short fatty acid chains or unsaturated fatty acids are oils. Examples embody oils from corn, olives, Phospholipids Similar to a fats molecule, a phospholipid consists of a glycerol portion with fatty acid chains. They are structurally associated to glycolipids and are literally modified triglycerides. The distinctive chemical properties of phospholipids come from the phosphorus-containing group. The heads of those molecules (the phosphorus-containing part) are polar, attracting other polar or charged particles (including ions or water). The unique phospholipids can be utilized as the primary material for the building of cell membranes. Steroids Steroid molecules are giant, basically flat lipid molecules that share a distinctive carbon framework as compared with fats or oils. All steroid molecules have the same fundamental structure: three six-carbon rings joined to one five-carbon ring. Cholesterol is an important steroid and is ingested in animal meals corresponding to cheese, eggs, and meat. Although essential for human life, extreme ldl cholesterol participates in atherosclerosis and related illness. In the cell membranes, cholesterol is the uncooked material that helps to synthesize vitamin D, bile salts, and steroid hormones. Eicosanoids Eicosanoids are lipids which are largely derived from arachidonic acid, a 20-carbon fatty acid existing in all cell membranes, crucial of that are the prostaglandins and related acids. Prostaglandins are essential for blood clotting, irritation, labor contractions, regulation of blood stress, and lots of different physique processes. Prostaglandin synthesis and inflammatory effects are blocked by drugs such as the cyclooxygenase inhibitors and nonsteroidal anti-inflammatory medicine. Explain the most common type of lipids and record the parts their molecules comprise. It may be a low stage of high-density lipoproteins, which contributes to the event of atherosclerosis. They make up between 10% and 30% of cell mass and are the fundamental structural materials of the physique. On cell surfaces, some proteins mix with carbohydrates to turn out to be glycoproteins. Proteins embrace biologic catalysts (enzymes), contractile proteins of muscle tissue, and the hemoglobin of the blood. Biochemistry forty three There are greater than 200,000 forms of proteins within the human body, the full set generally identified as the proteome. All proteins comprise carbon, hydrogen, oxygen, and nitrogen atoms, with small quantities of sulfur additionally current. Protein molecules consisting of amino acids held collectively by peptide bonds are called peptides, that are joined collectively by way of dehydration synthesis. Each kind of peptide is called for the quantity of amino acids which are united: dipeptide (2), tripeptide (3), polypeptide (10 or more), and so forth. Although most proteins are macromolecules, polypeptides that include more than 50 amino acids are known as proteins. Macromolecules are massive and sophisticated, with as few as one hundred to over 10,000 amino acids. The means they bind determines how the proteins they produce are structured and the way they perform. Types of Proteins Proteins are usually classified as either fibrous or globular. Fibrous proteins are longer and resemble "strands" and are highly stable and insoluble in water. Collagen, the most ample protein in the physique, is a fibrous protein as are elastin, keratin, and a few contractile proteins found in muscle tissue. Globular proteins are important in nearly all biologic processes and are subsequently additionally referred to as practical proteins.

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Support stockings dental pain treatment guidelines quality 500mg azulfidine, elevation, and remedy of related venous insufficiency can also enhance nodular vasculitis. Kabuto M, et al: Erythema induratum (nodular vasculitis) related to Takayasu arteritis. Papathemeli D, et al: Explosive generalization of nodular vasculitis�Mycobacterium marinum challenges the paradigm. Sekiguchi A, et al: Erythema induratum of Bazin related to bacillus Calmette�Gu�rin vaccination. This thick, tight, hyperpigmented skin outcomes from fibrosis within the subcutaneous fat, which may happen without the first inflammatory panniculitis ever being clinically noticed. These patients may have venous varicosities, superficial thrombophlebitis, deep venous thrombosis, or a quantity of of those conditions. Venous insufficiency ends in hypoxia, necrosis of fats, inflammation, and eventual fibrosis. If hypoxemia is current from different causes, such as pulmonary illness, sclerosing panniculitis may be extra severe. Angiosarcoma has been reported as a uncommon complication in the setting of postphlebitic lipodermatosclerosis. The histologic features of sclerosing panniculitis are characteristic, however not all features could additionally be seen on every biopsy, as a result of the histologic features change over time within the lesion. The overlying dermis frequently shows changes of stasis with nodular proliferation of thick walled vessels, hemosiderin deposition, fibrosis, and atrophy. Fat microcysts are characteristic (but not diagnostic) and seem as small cysts with feathery eosinophilic remnants of adipocytes lining the cyst cavity and resembling frost on a window, so-called lipomembranous fat necrosis. Despite these characteristic options, biopsy ought to be averted in these sufferers. Biopsies heal poorly and should result in persistent leg ulcers the prognosis can normally be made clinically. If a biopsy should be performed, it should be from essentially the most proximal fringe of involvement. This analysis can be clinically confirmed if a cautious vascular analysis is carried out. The gradual progression from the ankles proximally is characteristic of sclerosing panniculitis and not other forms of lobular panniculitis. Graded compression stockings with elevation and standard remedies for venous insufficiency are handiest on this situation. Application of strain dressings, such as an Unna boot, can produce dramatic, if temporary, enchancment. Greater compression-Unna boot with Coban and a foam buttress (bolster material to apply further stress to the red inflamed area) or the Profore boot-can be helpful. Intralesional triamcinolone and ultrasound remedy have been used, however this is best when used in conjunction with compression. The addition of hydroxychloroquine to pentoxiphylline might provide extra enchancment. Apparently, by enhancing the fibrinolytic capability of affected patients, stanozolol, or oxandrolone, might profit some sufferers. Stanozolol and oxandrolone may be virilizing for women and must be avoided in ladies of childbearing age. Surgical remedy of varicosities and incompetent perforators could end in dramatic improvement in some patients. Some are characterised by the presence of needle-like clefts: sclerema neonatorum, subcutaneous fat necrosis, and poststeroid panniculitis. Infants and kids are most regularly affected likely partially due the upper quantity of brown fat in children. Brown fats freezes into a strong at greater temperatures than common fats in adults, so slight cooling can lead to solidification and necrosis. Balasubramanyam S, et al: Venous therapy of lipodermatosclerosis to enhance ambulatory operate. Sclerema neonatorum is probably the most severe and rarest dysfunction of the bodily panniculitides. With extra enough neonatal intensive care, this dysfunction has turn into extremely uncommon. Neonates affected with sclerema neonatorum usually die, until the underlying diseases can be reversed. In the primary few days of life, the pores and skin begins to harden, often initially on the buttocks or lower extremities, then rapidly spreads to involve the entire body. The pores and skin turns into dry, furious, chilly, inflexible, and boardlike, limiting the mobility of the parts. Therapy is usually supportive, however some knowledge recommend trade transfusion might enhance survival. There is commonly a historical past of fetal distress corresponding to start asphyxia, maternal-fetal disproportion, or meconium aspiration. In general, the infants stay nicely; nevertheless, hypoglycemia, thrombocytopenia, hypertriglyceridemia, lactic acidosis, and probably life-threatening hypercalcemia could not often occur. Some diploma of hypercalcemia occurred in more than 50% of lately reported circumstances. The hypercalcemia could seem weeks to months after the appearance and backbone of the pores and skin lesions. Periodic measuring of serum calcium for the primary 3�6 months of life or until the lesions resolve has been beneficial as the calcium can enhance even because the lesions are resolving. Hypercalcemia might result in failure to thrive, irritability, lethargy, hypotonia, seizures, and renal failure. Significant hypercalcemia is treated with hyperhydration, calcium-wasting diuretics (furosemide), and formulas low in calcium and vitamin D. Systemic corticosteroids, calcitonin, and bisphosphonates can also be efficient when other methods fail to reduce the hypercalcemia. Needle-shaped clefts are arranged radially inside histiocytes, and multinucleate foamy histiocytes are present. Fine-needle aspiration and touch preparations can verify this analysis, and a biopsy is diagnostic. Subcutaneous Fat Necrosis of the Newborn et Histologically, adipocytes are enlarged and crammed with needle-like clefts in a radial array Recently, this unusual histologic discovering was documented in a reaction to gemcitabine. There is sparse inflammation, and histiocytes containing needle-like clefts are uncommon, probably as a result of most kids die earlier than granulomas can form. Ferrara G, et al: Cold-associated perniosis of the thighs ("equestrian-type" chilblain). Khedr S, et al: Occult huge visceral fats necrosis following therapeutic hypothermia for neonatal encephalopathy. Lopez V, et al: Usefulness of fine-needle aspiration in subcutaneous fat necrosis of the new child prognosis. Lesions happen inside a couple of days of the chilly software and seem as barely erythematous, nontender, firm subcutaneous nodules. Equestrian panniculitis on the higher outer thighs (although it can be medial) of individuals using horses within the cold more intently resembles a type of perniosis somewhat than true panniculitis (see Chap er 3). The commonest location of the lesions is near the perineum, in preserving with the area of greatest concentration of scrotal fat in kids. A combined inflammatory infiltrate of lymphocytes, neutrophils, and foam cells is present, and microcysts typically happen. Firm subcutaneous nodules start to appear inside 1 month of tapering the corticosteroids. Areas of abundant subcutaneous fat are favored: the cheeks, trunk, and proximal extremities. Most cases resolve spontaneously within weeks, but when extreme, the corticosteroids should be reinstituted and tapered extra slowly. Histologically, the adjustments are equivalent to those seen in subcutaneous fats necrosis of the newborn. There is a lobular panniculitis with necrosis of adipocytes and needle-shaped clefts in each adipocytes and histiocytes. Lesions present much like a lipoma, as a agency, mobile subcutaneous mass (formerly reported as cellular encapsulated lipoma). The term myospherulosis (spherulocytosis) has been used to describe subcutaneous cystic lesions induced by trauma with hemorrhage into areas of high lipid content Many cases are brought on by exogenous lipids from postoperative packing, usually in parasinus tissues or subcutaneous fat.

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Hormonal controls maintain blood calcium ions in a variety between 9 and 11 mg/dL (100 mL) of blood neck pain treatment quick fix buy 500 mg azulfidine otc. Children under age 10 want 400�800 mg of calcium of their day by day food regimen, whereas folks between ages eleven and 24 require 1,200�1,500 mg. It is the first hormonal controller of bone transforming, although calcitonin can additionally be concerned to a lesser diploma, elevated levels of calcium ions in the blood stimulate the secretion of the hormone calcitonin. However, if blood calcium ranges are low for a very long time, the bones lose minerals and develop giant, irregular holes. The adipose tissue releases the hormone leptin, which helps to regulate bone density, weight, and energy balance. Leptin seems to inhibit the actions of osteoblasts, via mediation by the hypothalamus, activating sympathetic nerves that serve bones. The stability between bone destruction and formation are regulated by interactive processes of the mind, skeleton, and intestine. Serotonin mediates these processes and is primarily manufactured in the intestine. Serotonin is secreted during consuming, circulating to the bones to interfere with osteoblast activity. Because bone turnover is decreased after eating, calcium may be held in bones whereas new calcium is shifting into the bloodstream. Serotonin uptake inhibitors make excessive serotonin out there to bone cells, leading to lower bone density and higher potential for fracture. On one facet, the bone is compressed by bending, whereas on the other facet, it experiences pressure (stretching). Long bones are, subsequently, thickest at the midpoint of the diaphysis as a result of this is where bending stresses are strongest. Without inflicting any serious problems, a bone could be hollowed out for lightness, which means utilizing spongy bone somewhat than compact bone. Large increases in bone strength occur from vigorous train of the most-used higher limb. Deformation of a bone causes an electrical present, with compressed and stretched regions having opposite costs. Within the canaliculi, the flowing of fluids seems to provide stimuli that control bone remodeling. Hormonal controls, in response to changing levels of blood calcium, decide when (and if) remodeling occurs. This can result in dangerous calcium salt deposition in the blood vessels and delicate organs such as the kidneys, which leads to kidney stones. Bone Homeostatic Imbalance 167 Bone Homeostatic Imbalance When imbalances happen between bone deposition and bone resorption, quite a lot of ailments can affect the skeleton corresponding to rickets (in children), osteomalacia (in adults), and osteoporosis (primarily in elderly women). However, if a mother develops osteomalacia as a end result of solar deprivation, nursing her toddler will pass her vitamin D deficiency through the breast milk, with the end result of the toddler creating rickets. Osteomalacia Osteomalacia really describes a selection of problems involving poor bone mineralization. The affected individual might really feel ache when weight is placed on affected bones (usually the lower backbone, pelvis, hips, legs, and ribs). Osteomalacia may result in an abnormal gait, decreased muscle tone, weak spot, and immobility. However, rickets is extra extreme because the bones of children are actively growing. Rickets, in addition to osteomalacia, is caused by inadequate dietary calcium or by vitamin D deficiency. The bones become extremely fragile, in a place to be fractured by walking down stairs or excessive hard sneezing. In osteoporosis, bone mass declines while the composition of the matrix remains the identical. The bones turn into porous and light, with the spongy bone of the spine being most susceptible. Osteoporosis is commonest in postmenopausal girls, although males develop it also. The most susceptible group for osteoporosis is Caucasian girls, with 30% experiencing a bone fracture consequently. Normal bone density is maintained by the intercourse hormones (estrogens in females and androgens in males). Bone density is balanced by selling deposit of new bone and by restraining the actions of osteoclasts. Vertebral our bodies are much less dense than normal, and the front of 1 vertebral physique has collapsed (arrow). Compare the compression fracture in this vertebral physique with the vertebra above during which the anterior and posterior surfaces are the identical top. She has hormone-related situations similar to hyperthyroidism, diabetes mellitus, or low blood ranges of thyroid-stimulating hormone. Ribcage Vertebral column Sacrum Coccyx Also, an individual at any age can develop osteoporosis because of immobility. Men with prostate cancer have a higher threat for osteoporosis because remedies for this cancer embrace androgen-suppressing medicine. Mild falls or stressful actions are capable of trigger osteoporotic bones to fracture, most frequently within the hips, wrists, or spine. Osteoporosis impacts women and men of each race, though postmenopausal white and Asian women are at highest risk. Medications, a nutritious diet, and weightbearing train may help prevent bone loss or strengthen bones which have already weakened. Certain cancers such as those of the breast, bone marrow, and different tissue release osteoclastactivating issue. This increases the amount and activity of osteoclasts, leading to extreme osteoporosis. Skeletal Organization 169 Axial Skeleton the axial skeleton supports and protects the pinnacle, neck, and trunk. It contains the cranium, hyoid bone (a single bone within the neck that helps the tongue and its muscles), vertebral column, and thoracic cage. The only movable bone within the skull is the mandible (lower jaw), which is connected to the skull by ligaments. Air-filled areas contained in the cranial bones known as paranasal sinuses assist the voice to resonate and likewise reduce the burden of the cranium. The cranial bones enclose the chamber that helps the mind, which is known as the cranial cavity. Cranium the skull consists of eight bones: Frontal bone: this bone forms the anterior cranium above the eyes, with every eye orbit (the eye socket) having a supraorbital foramen (notch). The frontal squama is also called the forehead, forming the anterior, superior portion of the skull. The lacrimal fossa is a shallow depression marking the placement of the lacrimal (tear) gland. Parietal bones: Located on all sides of the cranium behind the frontal bone, these two bones form the sides and roof of the skull and are fused within the center along the sagittal suture. Occipital bone: Joining the parietal bones alongside the lambdoid suture, the occipital bone types the back of the skull and base of the skull. A massive opening on the lower portion of this bone (the foramen magnum) allows nerve fibers to cross via from the mind into the spinal cord. The jugular foramen is between the occipital and temporal bones and permits the internal jugular vein to move by way of. Rounded occipital condyles on each side of the foramen magnum articulate with the first vertebra of the spine. The exterior occipital protuberance is a small bump on the inferior surface, on the midline, of the occipital bone. The external occipital crest begins here, marking the attachment of a ligament that helps stabilize the neck vertebrae. Temporal bones: these two bones be part of the parietal bone on all sides of the cranium alongside the squamous suture, and type components of the edges and base of the cranium. An opening known as the exterior acoustic meatus leads through each temporal bone to the inner ear. Two projections below each exterior acoustic meatus (the mastoid process and the styloid process) provide factors of attachment.

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